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Possibilities of physiotherapy in the treatment of spastic form of cerebral palsy
PORUBSKÁ, Ivana
This bachelor thesis deals with the topic of spastic paresis in the context of cerebral palsy. It consists of a theoretical and a practical part. The theoretical part of the thesis is structured into several chapters, which are devoted to the topics of cerebral palsy, spasticity and the possibilities of physiotherapy in the treatment of spastic paresis. The practical part is consist of qualitative research, which includes case studies of 2 pediatric patients with spastic form of cerebral palsy. In the conclusion of the thesis the results of the research and the effect of the chosen therapy are analyzed.
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Possibilities of physiotherapy for people with cerebral palsy
LINTNER, David
This bachelor thesis deals with the possibilities of physiotherapy for people with cerebral palsy (CP). The main goal is to apply these options within the medical rehabilitation plan. The theoretical part contains all the information on CP issues. It also includes developmental kinesiology, which is an integral part of the diagnosis and therapy of this disease. The last part contains a list of treatments that belong to complex therapy. The methodological part describes the process of research implementation, i.e. research sample, data collection methods, course of therapy, research ethics and research limits. The practical part is processed in the form of qualitative research, i.e. a case study, in which the input and output kinesiological analysis and subsequent therapy within a short-term and long-term rehabilitation plan are described in detail. The examination consists (apart from the anamnesis of the initial kinesiological analysis) of aspect, palpation, goniometry, orientation examination of strength, neurological examination, etc. The final kinesiological analysis showed that there was a positive effect of the therapy. The research lasted over a month and was prematurely terminated by the COVID-19 pandemic and the subsequent declaration of a state of emergency.
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Functional receptor alterations in urinary bladder and urethra in an animal model of chronic prostatitis-chronic pelvic pain syndrome
Rataj, Jan ; Štaud, František (advisor) ; Vokřál, Ivan (referee)
University of Gothenburg; Charles University Sahlgrenska Academy; Faculty of Pharmacy in Hradec Králové Institute of Neuroscience and Physiology; Department of Pharmacology & Toxicology Student: Jan Rataj Supervisor: Michael Winder, Ph.D.; Özgü Aydogdu, M.D.; Prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Functional receptor alterations in urinary bladder and urethra in an animal model of chronic prostatitis-chronic pelvic pain syndrome Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disorder. Current available pharmacological treatment options are not effective enough, mostly due to the etiology of CP/CPPS not being fully understood. My thesis aimed to examine potential urethral changes, using immunohistochemistry methods and an organ bath setup, in a rat model of CP/CPPS. The thesis also examined changes in the expression of muscarinic receptor subtype 3 (M3), β3 adrenoceptors, and purinergic P2X1 and P2X3 receptors in the urinary bladder using immunohistochemistry. Specifically, it was examined how these differ when celecoxib, BAY 60-2770 and a combination of celecoxib and BAY 60-2770 had been administered during the development of prostate inflammation in the rat model of CP/CPPS. The data show an upregulation of M3 receptors in animals with...
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Case Study of Physiotherapy Treatment of a Patient with the Diagnosis
Šňupárek, Václav ; Satrapová, Lenka (advisor) ; Neuwirthová, Svatava (referee)
Thesis name: Case Study of a Patient with Cerebral Palsy Goals: Goal of this work is to present theoretical requirements for leading a succesful therapy of patients diagnosed with cerebral palsy and to apply these findings in a therapy of a patient with cerebral palsy. Summary: This work is divided into two parts - theoretical and practical. In theoretical part there is defined cerebral palsy and its forms, there is described epidemiology, etiology and risk factors associated with cerebral palsy. There are presented methods and procedures based on which is the diagnosis of cerebral palsy made. The latter chapters are focused on treating patients with cerebral palsy, and based on thorough study of articles and other literature are added comments regarding effectivity of selected procedures and methods. Mainly rehabilitational methods are presented with emphasis on physiotherapy. There is a complete case study of a patient with cerebral palsy in the practical part. This part is consisted of anamnesis, entry physiotherapeutical examination, individual therapeutical sessions followed by exit physiotherapeutical examination. At the end there are the results and evaluation of the effects of the therapy. Empirical evidence based on which was this thesis made was collected during an internship in Dominiek...
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Possibility of Education for Pupils with Celebral Palsy within the Mainstream Education
NESVADBOVÁ, Helena
This bachelor thesis is devoted to the topic of educational possibilities for children with CP in the main educational stream in the city of České Budějovice. The first, theoretical part is focused on defining the CP, its diagnosis, classification and possible treatment methods. The next chapters look into history of education of handicapped children and the legislature which deals with the education of children with CP nowadays. The goal of this thesis is to explore the possibilities and processes of education of children with CP. This thesis is also trying to find out the opinions regarding this issue from parents, children and educational staff. The set goal is reached using quantitative research. This research was made using semi-structured interview with individual respondents and also the student's documentation was looked into. All respondents were contacted via directors or specialized educational staff of specific schools whom the request for cooperation was sent. The selected group of respondents was designed so that its structure corresponded with the goals of the thesis. The interviews were conducted in privacy without anyone else being present. The interviews with minors were conducted under the supervision of their legal guardian. The anonymity of all respondents was assured in the informed consent. Results of the research should be seen as basic information on the issue, because of relatively small number of respondents. After conducting the analysis, it is possible to say that children and pupils are satisfied with the given state of education. The result of research is the finding of insufficient usage of supportive means corresponding with current legislation. Most of the school included in the research are waiting for new examination of their pupils and also for explication of Special Pedagogy Center about possibilities of supportive measures funding. It would be suitable to review this thesis after for example two years in order to learn new information on the usage of supportive means and also possibilities of education of children with CP.
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Use of orthotic aids for children with cerebral palsy
PIPKOVÁ, Veronika
Cerebral palsy (CP) is a complex of disorders in the development of posture and ability to move which cause limitation of activity. It is an unprogressive disease, which begins in the prenatal, perinatal, or postnatal phase of a neonate. Although the disability does not progress, complex rehabilitation may improve the clinical state. There is a difference between the spastic and the non-spastic type. The major aim of this thesis is to map the possibilities of orthotic care for children suffering from CP and to evaluate the effect of physiotherapy with the use of chosen aids. Three probands suffering from hemiparetic CP participated in the research. The aim is to answer these research questions: What are the possibilities of orthotic care for children with cerebral palsy? What changes will occur in the postural behaviour of probands due to the physiotherapy with the use of orthotic aids? The theoretical part is concerned with the issues of CP. The disease is described in a general way and divided according to the time of beginning and type. Furthermore, the diagnostics and therapy are explained. It is also concerned with spasticity and its symptoms, mechanisms, diagnostics and therapy. An overview of orthotic aids, and experimental methods like posturography and surface electromyography are covered as well. The practical part deals with a qualitative research which was completed by case interpretations of three schoolchildren suffering from hemiparetic CP. The thesis includes an initial and a final kinesiologic analysis and a description of applied physiotherapies. Furthermore, it includes the results of posturogtaphy and surface electromyography focused on the orthotic aids used by the probands. The research took place in Centrum Arbida in České Budějovice and in the physiotherapy centre at the Faculty of Health and Social Sciences of The University of South Bohemia in České Budějovice. This thesis may be used as a comprehensive overview of the given issues and possibilities of orthotic therapy for children suffering from CP.
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Efekt xenobiotik na DNA integritu a fyziologii rybích spermií
LINHARTOVÁ, Pavla
Pollution of the aquatic environment with xenobiotics has become a serious health concern in recent years. In the present study the effect of DQ, TBBPA, BPA and VIN on sperm quality parameters, DNA integrity and oxidative stress indices in sterlet (Acipenser ruthenus) sperm and sperm from brook trout (Salvenilus fontinalis) were investigated. To do this, an in vitro spermatozoa motility assay was used by a computer-aided Motion-Analysis system. The sperm of sterlet (Acipenser ruthenus) was diluted to obtain the spermatozoa density of 5×108 cells×ml?1 and then exposed for 2 h to final concentrations of xenobiotics: DQ - 25, 50, 100 and 150 ?M, TBBPA - 0.5, 1.75, 2.5, 5, 7.5 and 10 ?g/l, BPA - 0.5, 1.75, 2.5, 5 and 10 ?g/l and Vin - 0.5, 1.75, 2.5, 5 and 10 ?g/l. Spermatozoa velocity and percentage of motile sperm were significantly decreased at each time post-activation compare to control. The level of DNA damage expressed as a % DNA in Tail and Olive Tail moment significantly increased when spermatozoa were exposed to higher concentrations of xenobiotics. The level of oxidative stress indices lipid peroxidation (LPO) and carbonyl derivatives of proteins (CP) and antioxidant activity of superoxide dismutase (SOD) increased significantly with increasing concentration of xenobiotics. On the other hand the intracellular ATP content in sperm samples had a significantly decreasing effect. In short, xenobiotics can induce reactive oxygen species (ROS) stress in fish spermatozoa, which could impair the sperm DNA integrity, quality and antioxidant defense system. The present study confirms that environmental concentrations of xenobiotics are capable to induce oxidative stress, leading to impaired sperm quality, DNA fragmentation and intracellular ATP content Obtained results also suggested that the use of fish spermatozoa in vitro assays may provide a novel and efficiently means for monitoring residual pharmaceutical in aquatic environment.
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